Tetracycline is a broad-spectrum antibiotic with a bacteriostatic effect.
Bacteriostatic antibiotic from the tetracycline group. It disrupts the formation of the complex between transfer RNA and the ribosome, which leads to suppression of protein synthesis.
Active regarding:
- gram-positive microorganisms: Staphylococcus spp. (including Staphylococcus aureus, including penicillinase-producing strains), Streptococcus spp. (including Streptococcus pneumoniae), Listeria spp., Bacillus anthracis, Clostridium spp., Actinomyces israelii;
- gram-negative microorganisms: Haemophilus influenzae, Haemophilus ducreyi, Bordetella pertussis, most enterobacteria: Escherichia coli, Enterobacter spp., including Enterobacter aerogenes, Klebsiella spp., Salmonella spp., Shigella spp., Yersinia pestis, Bartonella bacilliformis, Vibrio cholerae, Vibrio fetus, Rickettsia spp., Borrelia burgdorferi, Brucella spp. (in combination with ).
Microorganisms resistant to tetracycline: Pseudomonas aeruginosa, Proteus spp., Serratia spp., most strains of Bacteroides spp. and fungi, viruses, group A beta-hemolytic streptococci (including 44% of Streptococcus pyogenes strains and 74% of Streptococcus faecalis strains).
After oral administration, up to 66% of the dose taken is absorbed. Binds to plasma proteins by 65%. Penetrates well into various organs and tissues, as well as biological fluids: bile, synovial, ascites, CSF (in the latter the concentration is 10–25% of that in blood plasma), accumulates in bone tissue and teeth, liver, spleen, tumors. Penetrates through the placenta and into breast milk. Not metabolized, excreted in urine and bile.
Indications for use
What do Tetracycline tablets help with? According to the instructions, the drug is prescribed for the treatment of infectious and inflammatory diseases caused by microorganisms sensitive to tetracycline:
- pneumonia, tracheitis, bronchitis, pleural empyema;
- purulent soft tissue infections;
- pyelonephritis;
- endocarditis;
- prostatitis;
- whooping cough;
- rickettsial diseases;
- osteomyelitis;
- furunculosis, acne, infected eczema, folliculitis;
- cholecystitis;
- intestinal infections;
- endometritis;
- syphilis, gonorrhea;
- trachoma;
- brucellosis;
- tonsillitis, pharyngitis, otitis media;
- acne (pimples).
The drug is also used to prevent postoperative infectious complications in surgery.
Instructions for use Tetracycline, tablet dosage
The tablets are intended for oral administration. They are taken 1 hour before meals or 2 hours after meals, not chewed and washed down with a sufficient amount of water.
According to the instructions for use, Tetracycline tablets are prescribed in dosages of 250-500 mg 4 times a day or 500 mg - 1 gram 2 times a day. The maximum dosage is 4 grams per day.
For children, Tetracycline is used depending on the child’s body weight - at the age of 8–18 years, tablets are prescribed at 6.25–12.5 mg/kg body weight\ 4 times a day or at 12.5–25 mg/kg body weight\ 2 times a day.
The average duration of therapy varies between 7-10 days. The doctor prescribes the dosage, regimen and duration of the course of therapy individually.
special instructions
During treatment with Tetracycline, it is necessary to limit insolation, as photosensitivity may develop.
With long-term use of the drug, the function of the liver, kidneys and hematopoietic organs should be periodically monitored.
The instructions warn that Tetracycline can mask the symptoms of syphilis - if there is a possibility of a mixed infection, a serological test must be performed monthly (for 4 months).
To prevent hypovitaminosis while using Tetracycline tablets, it is advisable to additionally take brewer's yeast, vitamin K and B vitamins.
Side effects
The instruction warns about the possibility of developing the following side effects when prescribing Tetracycline:
- From the digestive system: nausea, vomiting, anorexia, abdominal pain, diarrhea, constipation, dry mouth, glossitis, discoloration of the tongue, esophagitis, transient increase in the activity of liver transaminases, alkaline phosphatase, bilirubin concentration, residual nitrogen.
- From the side of the central nervous system: dizziness, headache.
- From the hematopoietic system: neutropenia, thrombocytopenia, hemolytic anemia.
- Allergic reactions: skin rash, itching, eosinophilia, Quincke's edema.
- Dermatological reactions: photosensitivity.
- Effects caused by chemotherapeutic action: candidal stomatitis, vulvovaginal candidiasis, intestinal dysbiosis.
- Other: hypovitaminosis of B vitamins.
Contraindications
It is contraindicated to prescribe Tetracycline tablets in the following cases:
- Hypersensitivity to tetracycline;
- Impaired liver and kidney function;
- During pregnancy and breastfeeding;
- Leukopenia;
- Mycoses (fungal infections);
- Systemic lupus erythematosus;
- Age up to 8 years.
In this case, after preliminary lavage of the stomach and intestines, as well as taking intestinal sorbents ( Activated carbon) symptomatic therapy is carried out in a medical hospital, since there is no specific antidote.
Analogues of Tetracycline tablets, price in pharmacies
If necessary, you can replace Tetracycline with an analogue of the active substance - these are the following drugs:
- Glycocycline,
- Imex,
- Tetracycline-AKOS and Tetracycline-LekT,
- Tetracycline hydrochloride.
When choosing analogues, it is important to understand that the instructions for use of Tetracycline tablets, price and reviews do not apply to drugs with similar effects. It is important to consult a doctor and not change the drug yourself.
Price in Russian pharmacies: Tetracycline tablets 100 mg 20 pcs. – from 51 to 72 rubles, Tetracycline with Nystatin 0.1+0.0222 10 tablets – from 59 to 81 rubles, according to 309 pharmacies.
Store in a dry, dark place at 25 °C. Keep away from children. Shelf life – 3 years.
Dispensing conditions from pharmacies are by prescription.
Tetracycline tablets are antibacterial drugs which, as an active substance, contain tetracycline hydrochloride in the amount of one hundred milligrams per tablet. In addition to the active substance, the tablets include: starch, magnesium, calcium and gelatin. Stored at temperatures up to 25 o C, no more than three years.
pharmachologic effect
Tetracycline is very effective drug, which, due to its antibiotic action, suppresses the synthesis of proteins that have a destructive effect on substances produced by the body’s defense systems in most bacteria pathogenic to humans, such as:
- Streptococci;
- Listeria;
- Clostidia;
- Anaerobes;
- Spirochetes;
- Cyanobacteria;
- Green sulfur bacteria;
- Green non-sulfur bacteria;
- Anthrax;
- Haemophilus influenzae infection;
- Chlamydia trachomatis;
- Chlamydia psittaci;
- Dysenteric amoeba and many other harmful microorganisms.
Some of the listed strains are not susceptible to the effects of penicillin, so tetracycline tablets help in cases where, for one reason or another, the use of the penicillin group or similar drugs against spp. bacteria, gonococci, and actinomycetes SPP is impossible.
But not all microorganisms can be blocked by tetracycline tablets. The following are resistant to this drug:
- Proteus SPP;
- Bacteria serratia spp;
- Most strains of Bacteroides spp. and mushrooms;
- Viruses;
- Group A beta-hemolytic streptococci (including 44 percent of Streptococcus pyogenes strains and 74 percent of Streptococcus faecalis strains).
When taking tetracycline tablets orally on an empty stomach, the maximum concentration of the active substance in the blood plasma will be reached after 2-3 hours and will be 75-77 percent of the biological activity, and if the drug is taken with food, biological activity will drop to 55-65 percent. Over the next eight hours, the concentration will gradually decrease. For the drug to provide therapeutic resistance to bacteria, a content of 1 mg/l is sufficient, while the maximum permissible concentration is not more than 3.5 mg/l. It may take 2-3 days to achieve therapeutic levels of the substance in the blood.
Due to the different permeability of different membranes and media, tetracycline hydrochloride is unevenly distributed in the body. Approximately equal concentrations of the active substance are found in blood plasma, salivary, ascitic and pleural fluids, human milk, and in the prostate and thyroid glands. Largest quantity contained in lymphatic systems e, spleen, in the organs most actively involved in metabolic processes: kidneys, lungs, liver. And also in bone tissue, tumor formations in the enamel, dentin of baby teeth. The placenta is also not a barrier to tetracycline. But the membranes of the central nervous system allow this drug to pass through in very small quantities, and therefore, the treatment of diseases of the central nervous system with this drug is not as effective as other body systems.
The half-life is 8-11 hours; if urination is difficult, this period can increase to four days. From 2 to 12 hours after ingestion, it is present in the urine in high concentrations. During this period, the kidneys excrete about 20 percent of the dose taken. The rest is metabolized in the liver and excreted along with bile into the intestine, where some amount is absorbed back, providing enterohepatic circulation, which increases the duration of action of tetracycline.
Cleaning blood from traces of the drug by hemodialysis is not effective.
Indications for use
"Tetracycline-LekT" is widely used to combat many viral and bacterial infections that cause a whole bunch of pathologies to which the human body is susceptible. These are diseases of the respiratory system, skin, mucous and soft tissues, genitourinary and lymphatic systems, damage to vital organs and cells of the body.
However, many forms of yeast are very resistant to tetracycline hydrochloride. And since it suppresses the microflora competing with them, the “yeast” actively multiplies. This effect can be prevented by taking a combined antibacterial agent - tetracycline with nystatin tablets. Nystatin is a drug that actively affects precisely that form of bacteria that is resistant to the action of tetracycline. Thus, these two substances are an optimal complement to each other.
- Contraindications
- Individual intolerance to components;
- Children under 8 years old;
- Severe kidney and liver diseases;
- Low white blood cells;
Inability to digest fructose, isomaltase, and sucrose by the body;
Although tetracycline is rated D by the FDA, it is still recommended that pregnant women and new mothers avoid it while breastfeeding. In order not to expose the fetus and baby to the cumulative effect of the active substance, which can lead to developmental disorders of the skeleton, dental tissues or cause a hyperreaction to solar radiation and thrush in the child.
- special instructions
- Since the components of tetracycline tablets may cause an increased reaction to solar radiation, it is recommended not to sunbathe during treatment;
- Long-term use requires increased control over the functioning of the liver, kidneys and bone marrow;
- According to doctors' observations, the drug suppresses the symptomatic manifestations of syphilis. And, if there is a risk of infection while taking the medicine, you must take a serological test once a month for four months; While taking tetracycline, tooth enamel
may thin out a little and acquire yellow-gray or yellow-brown shades. This is not dangerous and goes away after completing the course of treatment. But it would be a good idea to enrich your diet with brewer’s yeast, vitamins B and K, and foods with a high calcium content. The instructions for use of tetracycline give the average rate for an adult, which is up to 0.5 g every 6 hours or up to 1 g twice a day. Limit quantity - 4 g.
For children over 8 years of age, up to 12.5 mg/kg every 6 hours or up to 25 mg/kg twice a day.
Side effect
The digestive system may respond with lack of appetite, diarrhea, vomiting, inflammation of the tongue, inflammation of the mucous membranes oral cavity and esophagus, ulcerative rashes in the stomach and intestines, disruption of the normal functioning of the kidneys, liver and gastrointestinal tract.
In the central nervous system disruptions are expressed in high intracranial pressure, migraines, disorientation in space, unstable body position.
Jaundice of the skin, decreased blood clotting, increased temperature, with general weakness, chills, possible tremors, tachycardia, a sharp decrease in blood pressure and other consequences of changes in blood composition.
An increase in blood creatinine and a decrease in nitrogen, impaired renal function.
Allergic rashes and redness on the skin, inflammation of the mucous membranes, possible angioedema.
Manifestations associated with a lack of vitamins, inflammation of the esophagus, darkening of tooth enamel, stomatitis.
Overdose
In case of overdose it is used symptomatic treatment plus a dosage reduction or complete discontinuation of tetracycline.
Interaction with other drugs
Reduces the effectiveness of bactericidal antibiotics that disrupt cell wall synthesis: penicillin, cephalosporin.
Reduces efficiency birth control pills containing estrogen; When taken simultaneously with retinol, intracranial pressure may increase.
The absorption of tetracycline hydrochloride is opposed by antacids, which contain: aluminum, magnesium and calcium, iron supplements and cholestyramine.
Chymotrypsin, on the contrary, increases the concentration and circulation period.
Antibiotic Tetracycline is a drug belonging to the tetracycline group. The group of tetracyclines and their derivatives (including semisynthetic ones) includes slightly more than 262 pharmacological drugs and almost 40 names. What unites them chemical structure: condensed 4-row system. The common structure determines a similar antimicrobial effect on the human body and the mechanism of influence.
The drug destroys gram-positive and gram-negative bacteria. Tetracycline is widely used as a drug for the treatment of various purulent skin diseases (including furunculosis, acne), inflammatory processes respiratory tract(sore throat, bronchitis, pneumonia, etc.) and genitourinary system(gonorrhea, syphilis, etc.).
This medication, in addition to its antibacterial effect, also has pronounced anti-inflammatory properties, which can significantly speed up the healing process.
The main active ingredient is Tetracycline 100 mg (1 tablet contains 100 mg of tetracycline hydrochloride, calculated as 100% substance). Tetracycline is available in the form of an ointment for external use 3%, an eye ointment 1%, tablets of 0.1 g and a suspension for the preparation of syrup.
Tetracycline is active against streptococci, staphylococci, Brucella, Bartonella and many other bacteria. The medicine fights chlamydia, clostridia, bacilli, treponema and other pathogenic microorganisms.
Tetracycline has a bacteriostatic effect on pathogenic microorganisms. Once in the body, Tetracycline blocks the synthesis of proteins by the bacterial cell, as a result of which the transfer of genetic information during its division is disrupted.
Indications for use Tetracycline
Tetracycline tablet for oral administration
The official instructions for the use of Tetracycline tablets indicate that they are effective for the following pathologies:
- All infectious diseases caused by pathogens sensitive to the drug.
- Infections of the skin, bones, soft tissues, mucous membranes (gingivitis, stomatitis, including ulcerative necrotic), acne, carbunculosis, furunculosis, suppuration of the skin, conjunctivitis.
- Intestinal amebiasis, cholera, anthrax, brucellosis, rickettsiosis, syphilis, tularemia, trachoma, yaws, listeriosis, uncomplicated gonorrhea, plague, granuloma inguinale, chlamydiasis, psittacosis, actinomycosis, etc.
- Bacterial infections of the respiratory and urinary tract.
Tetracycline ointment for local (external use)
- Ointment for external use: bacterial infections skin. Treatment of purulent skin infections: furunculosis, infected eczema, acne, folliculitis.
- Eye ointment: bacterial eye infections - blepharitis, blepharoconjunctivitis, keratitis, keratoconjunctivitis, meibomitis (styre), trachoma, eye damage due to rosacea.
Instructions for use Tetracycline, dosage
Tetracycline tablets
Tetracycline tablets are taken orally with plenty of water or other liquid. The average recommended dose for adults is 0.25–0.5 g four times a day or 0.5–1 g twice a day (every 12 hours). Maximum dose– 4 g per day.
– For acne, the recommended dose is 500 mg to 2 grams per day for 21 days. Then the dose is gradually reduced to a maintenance dose of 125 mg to 1 g.
- Brucellosis. 500 mg every 6 hours for 21 days. At the same time, it is recommended to prescribe streptomycin in therapeutic and age-specific dosages.
– Uncomplicated gonorrhea. Starting dose 1500 mg (1.5 g). subsequently 500 mg every 6 hours for 4 days.
- Syphilis. Early 500 mg every 6 hours for 15 days. Late 30 days.
Tetracycline ointment
Tetracycline in the form of an ointment is applied to areas of skin affected by infection, or used as gauze bandage, which is applied to the problem area. The frequency of application of the ointment is 1–2 times a day. The duration of use depends on the degree of skin damage and varies from 2 days to 2 weeks.
The duration of therapy with tetracycline antibiotics and the exact dosage can only be determined by a doctor, based on the characteristics of the patient and the course of the pathological process.
Tetracycline eye ointment
Tetracycline in the form of an ophthalmic ointment is used topically (in the eyes). The drug is placed behind the eyelid (in the conjunctival sac). A single dose is a strip of ointment 0.5–1 cm long.
To prevent hypovitaminosis, vitamins B and K should be prescribed, as well as brewer's yeast, which is rich in microelements, choline, thiamine, pyridoxine, pantothenic acid and folic acid, vitamins E, PP, H and provitamin D.
Features of application
There may be some blurriness after applying the eye ointment. visual perception, therefore, after instillation of the medication, it is not recommended to work with precision mechanisms or drive vehicles for half an hour. If the condition does not improve within a few days, you should consult your doctor.
During therapy, direct sunlight should be avoided due to the risk of photosensitization.
Tetracycline therapy should be carried out under medical supervision. You should strictly follow the prescription regimen throughout the course of treatment, do not skip doses and take them at regular intervals. If you miss a dose, take it as soon as possible; Do not take if it is almost time for the next dose. Do NOT double the dose.
Tetracycline should not be taken simultaneously with whole milk and other dairy products (kefir, cottage cheese, cheese, fermented baked milk, yogurt, etc.), as this interferes with the absorption of the drug.
Tetracycline is a fairly effective drug, but in many cases a combination with other antibacterial drugs is required. For example, with streptomycin.
All tetracyclines form stable complexes with Ca2+ in any bone-forming tissue. In this regard, intake during the period of tooth development can cause long-term staining of teeth in a yellow-gray-brown color, as well as enamel hypoplasia. Prolonged use of the product can lead to stomatitis.
During antibiotic therapy, the use of any type of alcohol is strictly contraindicated, due to the low adsorption of the active substance.
Side effects and contraindications Tetracycline
How adverse reactions possible: vomiting, redness of the skin (hyperemia), rash (urticaria), diarrhea, anorexia, epigastric pain, constipation, dry mouth, discoloration of the surface of the tongue and tooth enamel, headache, dizziness, itching.
Also possible: tissue swelling, increased photosensitivity, hypovitaminosis, intestinal dysbiosis, rapid heartbeat, increased blood pressure, instability, distraction, delayed reaction, passivity, weakness, loss of performance, allergic reactions, neutropenia, pancreatitis, duodenal ulcer.
Overdose
Cases of overdose have not been described. Possible increased manifestations of adverse reactions. Treatment is symptomatic.
Contraindications
Hypersensitivity to the drug and related antibiotics, fungal diseases, liver dysfunction, kidney disease, leukopenia, pregnancy, lactation (stop breastfeeding during treatment), childhood up to 8 years old.
Tetracycline analogues, list of drugs
- Deschlorbiomycin,
- Acromycin,
- Cyclomycin,
- Deschloraureomycin,
- Gostacyclin,
- Panmicin,
- Polycycline,
- Steklin,
- Tetrabon,
- Tetracine,
- Apothethra.
Important - instructions for use of Tetracycline, price and reviews do not apply to analogues and cannot be used as a guide to the use of drugs of similar composition or action. All therapeutic prescriptions must be made by a doctor. When replacing Tetracycline with an analogue, it is important to consult a specialist; you may need to change the course of therapy, dosage, etc. Do not self-medicate!
A medicine whose main active ingredient is tetracycline cannot be called harmless. A Tetracycline analogue (any of the group) will also have many contraindications. However, it should be remembered that the drug was prescribed by a doctor, and before that he must weigh the expected benefits of use and possible negative consequences.
TETRACYCLINE-BELMED is an antibiotic. The active substance, tetracycline hydrochloride, belongs to one of the groups of drugs - antibacterial agents for systemic use, tetracyclines.
TETRACYCLINE-BELMED is used to treat the following infections:
respiratory tract infections such as pneumonia, bronchitis and whooping cough
infections urinary tract
sexually transmitted diseases such as chlamydia infection, gonorrhea and syphilis
skin infections such as acne
eye infections such as conjunctivitis
Rickettsia infections such as Q fever and tick fever
other infections, including brucellosis, psittacosis, plague, cholera, leptospirosis, gas gangrene, tetanus.
Do not take this medicine if
You are allergic to tetracycline, other similar antibiotics (such as minocycline, doxycycline), or another part of this drug that is listed in the Ingredients section
You have suffered from kidney or liver disease for a long time or have severe kidney disease
you have systemic lupus erythematosus, a disease that causes rash (especially on the face), hair loss, fever, discomfort and joint pain
You are under 18 years old
You are pregnant or breastfeeding
you have a reduced number of leukocytes in your blood
Special instructions and precautions
Before using the drug TETRACYCLINE-BELMED; Consult your doctor if:
you have myasthenia gravis, a disease characterized by muscle weakness, difficulty chewing and swallowing, and slurred speech
You suffer from kidney or liver disease
You have increased sensitivity to sunlight
TETRACYCLINE-BELMED contains food dyes Carmoisine Lake and Ponceau 4R Lake, which can cause an allergic reaction.
Other drugs and Tetracycline-Belmed
Check with your doctor if you are taking, have recently taken, or may start taking any other medications. This also applies to any drugs sold without a prescription. Consult your doctor if you are using:
penicillins such as amoxicillin, flucloxacillin, phenoxymethylpenicillin
cephalosporins such as ceftriaxone, cefazolin, cefepime, cephalexin, cefixime and others
vitamin A
retinoids, such as tretinoin and adapalene, which are used to treat eczema, acne and other skin conditions
medications to thin the blood and prevent blood clots, such as warfarin and phenindione
drugs that increase urine output (diuretics), such as furosemide and spironolactone
medications to treat diarrhea, such as kaolin pectin and bismuth subsalicylate
chymotrypsin, which is used to treat purulent diseases
diabetes medications such as insulin, gliclazide and tolbutamide
drugs that can cause liver damage (ask your doctor if this applies to the drugs you are taking)
atovaquone, which is used to treat pneumonia
theophylline, used to treat diseases respiratory system
barbiturates and others medicines medications taken for seizures, such as carbamazepine, diphenylhydantoin, and primidone
antacids, which are used to treat indigestion and heartburn, as well as any medications containing aluminum, calcium, iron, magnesium, bismuth or zinc, because they may reduce the effectiveness of Tetracycline-Belmed
sucralfate, which is used to treat ulcers
lithium, which is used to treat mental disorders
digoxin, which is used to treat arrhythmias and heart failure
methotrexate, which is used to treat rheumatoid arthritis
strontium ranelate, which is used to treat osteoporosis
colestipol, cholestyramine, which are used to lower cholesterol levels
ergotamine and methysergide, which are used to treat and prevent migraines
methoxyflurane (anesthetic). If you need surgery, tell your doctor or dentist that you are taking TETRACYCLINE-BELMED
TETRACYCLINE-BELMED may reduce the effectiveness of oral contraceptives. During treatment, additionally use another method of contraception.
TETRACYCLINE-BELMED with food, drinks and alcohol
The drug should be taken orally one hour before or 2 hours after meals.
Do not take TETRACYCLINE-BELMED with food, milk or dairy products, as they may reduce the effectiveness of the drug.
Operations and tests
If you are being treated for a medical condition, tell your doctor or dentist that you are taking TETRACYCLINE-BELMED.
With long-term treatment, blood tests and assessment of kidney and liver function may be necessary.
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Pregnancy, breastfeeding and fertility
If you are pregnant or breastfeeding, think you may be pregnant, or are planning to become pregnant, consult your doctor before using this medicine.
Do not use this drug during pregnancy or breastfeeding unless your doctor thinks it is necessary. TETRACYCLINE-BELMED may affect your child's development.
Driving vehicles and working with machinery
TETRACYCLINE-BELMED does not affect the ability to drive vehicles and operate machinery.
Application
Always take this medication as directed by your healthcare professional. If in doubt, consult your doctor.
TETRACYCLINE-BELMED should be taken:
Your doctor will tell you what dose is best for you because... it depends on your condition. Take TETRACYCLINE-BELMED for at least 10 days, unless your doctor gives you other recommendations.
Adults and older people:
250 mg every 6 hours. The first dose may be 500 mg (5 tablets). For severe infections, your doctor may prescribe 500 mg (5 tablets) every 6 hours.
Features of use for certain infections:
skin infections: 250-500 mg per day in one or more doses for 3 months
brucellosis: 500 mg 4 times a day in combination with streptomycin
sexually transmitted diseases: 500 mg 4 times a day for 7-30 days depending on your condition
Use in children
Due to the presence of carmoisine (E-122) in the dye, TETRACYCLINE-BELMED is contraindicated for use in children.
Tetracycline can cause long-term staining of tooth enamel and affect skeletal bone development.
Mode of application
Take TETRACYCLINE-BELMED with a glass of water one hour before or two hours after meals.
Swallow the tablet while sitting or standing, and do not take the drug immediately before bed.
If you used more TETRACYCLINE-BELMED, you should
If you have taken too much TETRACYCLINE-BELMED, consult your doctor immediately. Symptoms of overdose include nausea, crystals or blood in the urine, and hypersensitivity reactions.
If you missed taking TETRACYCLINE-BELMED
If you miss taking TETRACYCLINE-BELMED, take it as soon as you remember. But if it is almost time for your next dose, wait until the allotted time and take your usual dose of the drug. Do not take a double dose to make up for a missed dose.
If you stop taking TETRACYCLINE-BELMED early
Continue taking TETRACYCLINE-BELMED for as long as your doctor prescribed, even if you feel better. If you do not complete the course of treatment, the infection may return.
Possible adverse reactions
Like all medicines, TETRACYCLINE-BELMED can cause side effects, although not everyone gets them.
Stop taking TETRACYCLINE-BELMED immediately and contact your doctor if you experience any of the following adverse reactions - You may need emergency health care:
sudden swelling of the lips, face, throat or tongue, rash, difficulty swallowing or breathing. These symptoms may be signs of a severe allergic reaction (anaphylaxis) and may be life-threatening
severe headache, dizziness, ringing in the ears, blurred vision, blind spots and double vision. These symptoms may be signs of high intracranial pressure
a rash that looks like a target or circles, often with blisters in the center. Later, blisters may cover a larger area and the skin may begin to peel. You may also experience sores in the mouth, throat, nose, or external genitalia, red and swollen eyes (conjunctivitis), and flu-like symptoms. The listed phenomena are characteristic of Stevens-Johnson syndrome and toxic epidermal necrolysis, which are life-threatening
deterioration or loss of vision
severe or prolonged diarrhea with blood or mucus - this may be a sign of severe intestinal inflammation
Abdominal and back pain may be a sign of inflammation of the pancreas (pancreatitis).
The following adverse reactions may occur:
Rarely(may affect less than 1 in 1000 people);
inflammation of the liver (hepatitis), liver failure, yellowing of the skin or whites of the eyes (jaundice), changes in liver function (determined by a blood chemistry test)
increased levels of urea, phosphate or blood acidity, changes in the number and types of blood cells. If you notice frequent bruising, bleeding, sore throat, infections, fever, constant feeling fatigue, shortness of breath or unusual pale skin - tell your doctor; you may need to have a blood test
throat ulcers, difficulty swallowing
kidney problems causing changes in urine, fatigue, weakness, shortness of breath and swelling due to fluid retention in the body.
Frequency unknown(frequency cannot be estimated from available data):
increased sensitivity to sunlight or artificial ultraviolet radiation, causing itching and burning of the skin. You should avoid sunlight and ultraviolet radiation
overgrowth of resistant microorganisms that leads to infections such as thrush
pseudomembranous colitis, symptoms of which include diarrhea, abdominal discomfort and fever
exacerbation of systemic lupus erythematosus, which manifests itself as rash, fever and joint pain
increased muscle weakness in patients suffering from myasthenia gravis
headache
upset stomach, nausea, diarrhea, loss of appetite, staining of tooth enamel, inflammation of the pancreas (pancreatitis), which causes abdominal discomfort and pain
impaired kidney function that causes changes in urinary frequency, swelling of the legs or ankles
fatty liver, which causes fatigue and pain in the upper abdomen
change in the color of the thyroid gland (it is not known whether its function is impaired).
Reporting Adverse Reactions
If you experience any unwanted reactions, consult your doctor. This also applies to any side effects that are not listed in this leaflet. You can also report adverse reactions to the Adverse Drug Events Information Database, including reports of ineffectiveness medicines identified on the territory of the state (UE “Center for Expertise and Testing in Healthcare of the Ministry of Health of the Republic of Belarus”, rceth.by). By reporting adverse reactions, you can help provide more information about the safety of the drug.
Compound
Active ingredient The drug TETRACYCLINE-BELMED is tetracycline hydrochloride – 100 mg.
Excipients: potato starch, povidone K-25, calcium stearate, sodium lauryl sulfate, microcrystalline cellulose, Aquarius Preferred Pink. Aquarius Preferred Pink shell composition: hydroxypropyl methylcellulose, copovidone, polydextrose, polyethylene glycol 3350, caprylic/capric triglycerides (medium chain triglycerides), titanium dioxide, carmoisine Lake (20-26%), Ponceau 4R Lake.
Appearance of the drug and contents of the package
Tablets, coated film-coated, pink, round, biconvex. The core is visible on the fault yellow color. The roughness of the film coating is allowed on the surface of the tablets.
10 tablets in a blister pack made of polyvinyl chloride film and aluminum foil. One or two contour packages together with an insert sheet are placed in a cardboard pack.
Marketing Authorization Holder and Manufacturer:
RUE "Belmedpreparaty"
Republic of Belarus, 220007, Minsk,
st. Fabricius, 30, tel./fax: (+375 17) 220 37 16,
Latin name: Tetracycline
ATX code: S01AA09
Active substance:
Manufacturer: Belmedpreparaty,
Belarus, etc.
Conditions for dispensing from a pharmacy: On prescription
Price: from 30 to 130 rub.
"Tetracycline" is an antibiotic with a broad spectrum of action. Used to treat infectious and inflammatory diseases.
Indications for use
The drug is prescribed for the following diseases: intestinal infections, external inflammation of the eyes, skin, lung membranes (pleurisy), acne, gonorrhea, prostatitis, endometritis, syphilis, purulent infections, trachoma.
Also indicated for: tetanus, botulism, conjunctivitis, brucellosis, granuloma inguinale and other diseases that are sensitive to antibiotics of this group.
Compound
The tablets contain tetracycline and such excipients as: vanillin, cocoa, water, sucrose, talc, gelatin, potato starch, calcium stearate monohydrate.
The eye ointment contains tetracycline in the amount of 10 mg, as well as anhydrous lanolin and petroleum jelly.
Medicinal properties
Like other drugs that belong to the tetracycline group, it is an antibiotic with an antibacterial effect that treats wide range diseases. Actively interacts with gram-positive and gram-negative microorganisms, as well as other pathogens infectious diseases, including STDs (sexually transmitted diseases), and other bacteria sensitive to antibiotics.
Antibiotics of this class are derived both culturally and artificially. It is considered no less effective than the new generation of antibiotics.
The drug is also used in veterinary medicine. Veterinarians give it to chickens, calves, arctic foxes, and use it in the treatment of young domestic animals.
Average price from 90 to 130 rubles.
Tetracycline tablets and capsules
One capsule contains 0.25 g of active substance (not produced by domestic pharmacists). In tablets, 0.05 is also added to this dosage; 0.125 and 1 g. The tablets are pink or brown (depending on the manufacturer), round in shape.
The average price is from 4500 to 6000 rubles.
Mode of application
Take 1-2 capsules 4 times a day or 2-4 every 12 hours (based on the recommendation of your doctor). The maximum permissible dose per day is 4 g. The capsules should be swallowed without chewing.
Tablets: for adults, take 0.2-0.25 g 3-4 times a day with water. Give children 20-25 mg per 1 kg of weight per day. The course of treatment lasts from 5 to 7 days.
Once the symptoms have passed, the drug should be continued for the next 1-3 days.
The average price is from 30 to 50 rubles.
Available in aluminum tubes of 10 or 15 grams. It can also be packaged in glass jars of 25 or 45 g. The concentration of the substance in it reaches 3%. The color of the ointment is white, possibly yellowish or brown. Thick to the touch.
The domestic manufacturer Synthesis produces it under the name “Tetracycline-Akos”.
Mode of application
The ointment is applied externally to damaged areas of the skin 1-2 times a day. If the patient uses tetracycline ointment for acne, the duration of treatment can range from 3-4 to 14 days, depending on the complexity of the inflammation.
The average price is from 50 to 70 rubles.
Tetracycline eye ointment
Available in tubes of 3 or 10 grams. The concentration of the eye ointment differs from the usual one and is 1%. External properties are similar to simple tetracycline ointment.
Mode of application
The drug is used topically. Apply every 2-4 hours behind the lower eyelid (on each eye). The duration of treatment depends on the form of the disease. Sometimes it can reach a period of one or even two months (with trachoma).
Contraindications
Prohibited use is: liver failure, pregnancy, lactation. Contraindicated for children early age(only possible after 8 years).
During pregnancy and breastfeeding
The use of tetracycline in pregnant women and women breastfeeding is undesirable. The active substances of the drug tetracycline in most forms penetrate the placental barrier, which negatively affects the health of the fetus; as well as on the color of teeth, the quality of tooth enamel and fatty infiltration of a woman’s liver. Eye drops and ointments are not dangerous, since a small amount of medicine ends up in the body.
Precautionary measures
Avoid direct contact with sunlight to avoid severe photosensitivity. Do not use the ointment for severe burns and deep wounds.
If, a few days after using the eye ointment, vision clarity has not been restored, you should consult a doctor. To prevent possible hypovitaminosis, it is recommended to consume vitamins B and K. Refrain from driving vehicles and activities that require high reaction and concentration.
Due to the fact that the drug can mask the symptoms of syphilis, in order to avoid mixed infections it is necessary to undergo testing for seromarkers within 4 months. You also need control over the functioning of the kidneys, intestines, liver, and blood circulation.
Determination of authenticity is carried out by carrying out a reaction with iron ions.
Cross-drug interactions
Due to the avoidance of an acid reaction, it is not recommended to take tetracycline in combination with drugs containing metal ions that are acid-sensitive; as well as bactericidal drugs: penicillin, cephalosporin groups.
Tetracycline is ineffective when interacting with cholestyramine, colestipol; If you take tetracycline and retinol at the same time, this can lead to increased intracranial pressure.
For veterinary purposes
Tetracycline hydrochloride is also used in the treatment of animals: poultry (in particular chickens) and cattle. Form: powder in a sealed bottle with a capacity of 20 ml, with a rubberized strong lid.
When the intestines are blocked, hens and chicks are given 20-30 grams of tablets crushed into powder diluted in water to drink. In case of inflammation (redness) of the eyes of chickens, eye ointment is prescribed for the poultry.
If there are problems with the respiratory system of chickens and chickens (wheezing, colds, inflammation of the trachea, bronchi, lungs), it is also recommended for chickens to drink tetracycline powder diluted in water.
When treating calves for pneumonia, pasteurellosis, colibacillosis and other diseases sensitive to tetracycline antibiotics, calves are given 20 mg of the drug twice a week. It is not recommended to slaughter calves and chickens for meat if a week has not passed since the last dose of the drug. The meat of killed calves and chickens before term can be used as food for fur-bearing animals or for the production of meat and bone meal.
Side effects
Possible side effects: vomiting, redness of the skin, rash, diarrhea, anorexia, abdominal pain, constipation, dry mouth, discoloration of the surface of the tongue and tooth enamel, headache, dizziness, itching. Swelling, increased photosensitivity, hypovitaminosis, intestinal dysbiosis, rapid heartbeat, high blood pressure, instability, absent-mindedness, delayed reaction, passivity, allergic reactions, neutropenia, pancreatitis, duodenal ulcer.
Overdose
If the specified norm is exceeded, both people and animals may experience an increase in the side effects listed above. In this case, you need to start symptomatic treatment.
Conditions and shelf life
Store for no more than 3 years in a dry place, at a temperature not exceeding 20 C.
Analogs
Tetracycline has many analogues that have similar properties and perform the same function. List of drugs that are prescribed along with tetracycline:
NIZHFARM, Russia
Price from 115 to 150 rub.
"Levomekol" is an ointment for external use with an antibacterial effect, it belongs to a new generation of antiseptics. When treating animals, Levomekol has a regenerating effect and treats other purulent-inflammatory diseases. Give to chickens when their eyes fester.
Levomekol is used by applying the ointment to a napkin and then blotting the wound; it is also used as an eye ointment.
pros
- Long shelf life
- Cheap drug
Minuses
- Narrower spectrum of action than tetracycline
- One release form
- Animals may be allergic to Levomekol.
Dalkhimpharm OJSC, Russia
Price from 10 to 300 rub.
Antibiotic (4th generation) for local application for eye treatment purposes. "Levomycetin" treats and prevents eye diseases such as conjunctivitis and keratitis. “Levomitin” is active even against those bacteria that are resistant to antibiotics of the tetracyclines, sulfonides, and penicillins. "Levomycetin" is also used to treat animals (given to calves, arctic foxes, chickens).
pros
- Lower price (from 15 rub.)
- Easily absorbed (especially drops)
Minuses
- "Levomycetin" is useless in the fight against acid-fast bacteria
- Bitter taste of tablets - it is extremely important to swallow the tablet quickly or drink a significant amount of water.
Biosynthesis, Russia, etc.
Price from 70 to 100 rub.
Antimicrobial drug. Absolute synonym of Tetracycline (base). Can be used both internally and externally. Available in tablets, solution and powder for its preparation.
pros
- Tetracycline hydrochloride has a higher solubility in water than just Tetracycline.
- When administered intramuscularly, the antibiotic is absorbed within half an hour and is completely excreted in the urine after 10-12 hours.
Minuses
- Tetracycline hydrochloride loses activity in solution very quickly, so it should be used immediately after preparing the solution
- Insulation may occur at the injection site - then you should stop using tetracycline hydrochloride.