Fur instructions for use. Furamag. Influence on concentration

Registration certificate holder:
OLAINFARM AS

ATX code for FURAMAG

J01XE (Nitrofuran derivatives)

Analogues of the drug according to ATC codes:

You should consult your doctor before using FURAMAG. These instructions for use are for informational purposes only. For more information, please refer to the manufacturer's annotation.

Clinical and pharmacological group

06.041 (Antibacterial drug, a derivative of nitrofuran)

Release form, composition and packaging

Capsules hard gelatin, size No. 4, brownish-yellow; the contents of the capsules are orange-brown to reddish-brown powder, white, yellow, orange and orange-brown particles are allowed.

Excipients: magnesium hydroxycarbonate, potassium carbonate, talc.

The composition of the gelatin capsule No. 4: titanium dioxide (E171), iron dye yellow oxide (E172), gelatin.

Capsules hard gelatin, size No. 3, yellow; the contents of the capsules are orange-brown to reddish-brown powder, white, yellow, orange and orange-brown particles are allowed.

Excipients: basic magnesium carbonate, potassium carbonate, talc.

The composition of the gelatin capsule No. 3: titanium dioxide (E171), quinoline yellow dye (E104), gelatin.

10 pieces. - blisters (2) - cardboard packs. 10 pcs. - blisters (3) - cardboard packs. 10 pcs. - blisters (4) - cardboard packs. 10 pcs. - blisters (5) - packs of cardboard.

pharmachologic effect

A broad-spectrum antimicrobial agent belonging to the group of nitrofurans.

Resistance to Furamag develops slowly and does not reach a high degree.

Active against gram-positive cocci: Streptococcus spp., Staphylococcus spp.; gram-negative rods: Escherichia coli, Salmonella spp., Shigella spp., Proteus mirabilis, Klebsiella spp., Enterobacter spp.; protozoa: Lamblia intestinalis and other microorganisms resistant to antibiotics.

In relation to Staphylococcus spp., Escherichia coli, Aerobacter aerogenes, Bacterium citrovorum, Proteus mirabilis, Proteus morganii, Furamag® is more active than other nitrofurans.

Against most bacteria, the bacteriostatic concentration ranges from 1:100,000 to 1:200,000. The bactericidal concentration is about 2 times higher.

Under the influence of nitrofurans in microorganisms, the respiratory chain and the tricarboxylic acid cycle (Krebs cycle) are suppressed, as well as other biochemical processes of microorganisms are suppressed, resulting in the destruction of their shell or cytoplasmic membrane.

As a result of the action of nitrofurans, microorganisms release less toxins, and therefore an improvement in the general condition of the patient is possible even before a pronounced suppression of the growth of microflora. Nitrofurans activate the body's immune system: they increase the complement titer and the ability of leukocytes to phagocytize microorganisms. Furazidin in therapeutic doses stimulates leukopoiesis.

Pharmacokinetics

Suction

After taking the drug inside, furazidin is absorbed in the small intestine by passive diffusion. The absorption of nitrofurans from the distal segment of the small intestine exceeds the absorption from the proximal and medial segments by 2 and 4 times, respectively (should be taken into account in the simultaneous treatment of urogenital infections and gastrointestinal diseases, in particular chronic enteritis). Nitrofurans are poorly absorbed from the colon.

Cmax in blood plasma lasts from 3 to 7 or 8 hours, furazidin is detected in the urine after 3-4 hours.

Being a mixture of the potassium salt of furazidin and basic magnesium carbonate in a ratio of 1: 1, Furamag®, when administered orally, has a higher bioavailability than simple furazidin (after taking the Furamag capsule in the acidic environment of the stomach, potassium furazidin does not turn into poorly soluble furazidin).

Distribution

Furazidin is evenly distributed in the body. Clinically important is the high content of the drug in the lymph (delays the spread of infection through the lymphatic tract). In bile, its concentration is several times higher than in serum, and in cerebrospinal fluid - several times lower than in serum. In saliva, the furazidin content is 30% of its serum concentration. The concentration of furazidin in the blood and tissues is relatively low, which is associated with its rapid release, while the concentration in the urine is much higher than in the blood.

Metabolism

Slightly biotransformed (

breeding

Unlike nitrofurantoin (furadonin), urine pH does not change after taking Furamag. 4 hours after taking the drug, the concentration of furazidin in the urine significantly exceeds the concentration that is formed after taking the same dose of furagin.

Excreted by the kidneys by glomerular filtration and tubular secretion (85%), partially undergoes reverse reabsorption in the tubules. At low concentrations of furazidin in the urine, the process of filtration and secretion predominates, at high concentrations secretion decreases and reabsorption increases. Furazidin, being a weak acid in acidic urine, does not dissociate, undergoes intensive reabsorption, which can increase the development of systemic side effects. With an alkaline urine reaction, the excretion of furazidin is enhanced.

Pharmacokinetics in special clinical situations

With a decrease in the excretory function of the kidneys, the intensity of metabolism increases.

FURAMAG: DOSAGE

The drug should be taken orally after meals.

Adults are prescribed 50-100 mg 3 times / day.

Children are prescribed 25-50 mg 3 times / day (but not more than 5 mg / kg of body weight per day).

The course of treatment is 7-10 days. If you need to repeat the course of treatment, you should take a break for 10-15 days.

For the prevention of infection (including during urological operations, cystoscopy, catheterization), the drug is prescribed for adults at 50 mg, for children - at 25 mg once 30 minutes before the procedure.

If a dose is missed, the next dose should be taken at the usual time. Do not take a double dose to make up for a missed dose.

Overdose

Symptoms: neurotoxic manifestations, ataxia, tremor.

Treatment: drink plenty of fluids. For cupping acute symptoms use antihistamines. For the prevention of neuritis, it is possible to prescribe vitamins (thiamine bromide).

drug interaction

Furamag® should not be used simultaneously with ristomycin, chloramphenicol, sulfonamides (the risk of hematopoietic inhibition increases).

Pregnancy and lactation

The use of the drug during pregnancy and lactation (breastfeeding) is contraindicated.

FURAMAG: SIDE EFFECTS

From the digestive system: rarely - nausea, vomiting, loss of appetite, abnormal liver function.

From the CNS and peripheral nervous system: rarely - headache, dizziness, polyneuritis.

Allergic reactions: rarely - skin rash (including papular rashes).

Furamag® has low toxicity.

Terms and conditions of storage

The drug should be stored out of the reach of children, dry, dark place at a temperature not exceeding 25°C. Shelf life - 3 years.

Indications

Infections caused by susceptible microorganisms:

  • urogenital infections (acute cystitis,
  • urethritis,
  • pyelonephritis);
  • gynecological infections;
  • skin and soft tissue infections;
  • severe infected burns;
  • for prophylactic purposes during urological operations (incl.
  • cystoscopy,
  • catheterization).

Contraindications

  • severe chronic renal failure;
  • pregnancy;
  • lactation period (breastfeeding);
  • children's age up to 3 years (for this dosage form);
  • hypersensitivity to drugs of the nitrofuran group.

With caution, the drug is used with a deficiency of glucose-6-phosphate dehydrogenase.

special instructions

To reduce the likelihood of side effects, Furamag® is washed down with a large amount of liquid.

If side effects occur, the use of the drug should be discontinued (toxic effects are more common in patients with reduced renal excretory function).

The patient must inform the physician of any side effects occurring during drug treatment.

Influence on the ability to drive vehicles and control mechanisms

No effect on the ability to drive vehicles and control mechanisms was noted.

Use for impaired renal function

Toxic effects as a result of the use of the drug are more likely to occur in patients with reduced renal excretory function (intensity of furazidin metabolism increases).

Furamag (caps. 25mg N30) Latvia Olainfarm JSC

LSR-002179/08.

INN Furazidin &
Trade name Furamag
Registration number LSR-002179/08
Date of registration 28.03.2008
Cancellation date
Producer Olainfarm JSC - Latvia

Packaging:
No. Packing ID EAN
1 capsules 25 mg 10 pcs.
2 capsules 25 mg 10 pcs.
3 capsules 25 mg 10 pcs.
4 capsules 25 mg 10 pcs.

Description (Vidal):

FURAMAG® (FURAMAG)

Representation:
OLAINPHARM JSC ATX code: J01XE Marketing authorization holder:
OLAINFARM AS
furazidin

Release form, composition and packaging

Capsules hard gelatinous, No. 4, brownish-yellow; the contents of the capsules are orange-brown to reddish-brown powder, white, yellow, orange and orange-brown particles are allowed. 1 caps.
furazidin (as potassium salt) 25 mg

Excipients: magnesium hydroxycarbonate, potassium carbonate, talc.

The composition of the gelatin capsule: titanium dioxide (E171), iron dye yellow oxide (E172), gelatin.




Capsules hard gelatinous, No. 3, yellow; the contents of the capsules are orange-brown to reddish-brown powder, white, yellow, orange and orange-brown particles are allowed. 1 caps.
furazidin (as potassium salt) 50 mg

Excipients: magnesium carbonate basic.

10 pieces. - blisters (2) - packs of cardboard.
10 pieces. - blisters (3) - packs of cardboard.
10 pieces. - blisters (4) - packs of cardboard.
10 pieces. - blisters (5) - packs of cardboard.
20 pcs. - bottles (1) - packs of cardboard.
30 pcs. - bottles (1) - packs of cardboard.
40 pcs. - bottles (1) - packs of cardboard.
50 pcs. - bottles (1) - packs of cardboard.

Clinico-pharmacological group: Antibacterial drug, nitrofuran derivative

Registration Nos.:
caps. 50 mg: 20, 30, 40 or 50 pcs. - P No. 014425/01, 18.03.08
caps. 25 mg: 20, 30, 40 or 50 pcs. - LSR-002179/08, 03/28/08
Description of the drug is based on officially approved instructions for use and approved by the manufacturer for the 2009 edition.
Pharmacological action | Pharmacokinetics | Indications | Dosing regimen | Side effect| Contraindications | Pregnancy and lactation | Special Instructions | Overdose | drug interaction| Terms of dispensing from pharmacies | Storage conditions and expiration dates
pharmachologic effect

A broad-spectrum antimicrobial agent belonging to the group of nitrofurans.

Resistance to Furamag develops slowly and does not reach a high degree.

Active against gram-positive cocci: Streptococcus spp., Staphylococcus spp.; gram-negative rods: Escherichia coli, Salmonella spp., Shigella spp., Proteus spp., Klebsiella spp., Enterobacter spp.; protozoa: Lamblia intestinalis and other microorganisms resistant to antibiotics.

In relation to Staphylococcus spp., Escherichia coli, Aerobacter aerogenes, Bacterium Citrovorum, Proteus mirabilis, Proteus morganii, Furamag is more active than other nitrofurans.

Against most bacteria, the bacteriostatic concentration ranges from 1:100,000 to 1:200,000. The bactericidal concentration is about 2 times higher.

Under the influence of nitrofurans in microorganisms, the respiratory chain and the tricarboxylic acid cycle (Krebs cycle) are suppressed, as well as other biochemical processes of microorganisms are suppressed, resulting in the destruction of their shell or cytoplasmic membrane.

As a result of the action of nitrofurans, microorganisms release less toxins, and therefore an improvement in the general condition of the patient is possible even before a pronounced suppression of the growth of microflora. Nitrofurans activate the body's immune system: they increase the complement titer and the ability of leukocytes to phagocytize microorganisms. Furazidin in therapeutic doses stimulates leukopoiesis.

Pharmacokinetics

Suction

After taking the drug inside, furazidin is absorbed in the small intestine by passive diffusion. The absorption of nitrofurans from the distal segment of the small intestine exceeds the absorption from the proximal and medial segments by 2 and 4 times, respectively (should be taken into account in the simultaneous treatment of urogenital infections and gastrointestinal diseases, in particular chronic enteritis). Nitrofurans are poorly absorbed from the colon.

Cmax in blood plasma lasts from 3 to 7 or 8 hours, furazidin is detected in the urine after 3-4 hours.

Being a mixture of the potassium salt of furazidin and magnesium carbonate basic in a ratio of 1: 1, Furamag, when administered orally, has a higher bioavailability than simple furazidin (after taking the Furamag capsule in the acidic environment of the stomach, potassium furazidin does not turn into poorly soluble furazidin).

Distribution

Furazidin is evenly distributed in the body. Clinically important is the high content of the drug in the lymph (delays the spread of infection through the lymphatic tract). In bile, its concentration is several times higher than in serum, and in cerebrospinal fluid - several times lower than in serum. In saliva, the furazidin content is 30% of its serum concentration. The concentration of furazidin in the blood and tissues is relatively low, which is associated with its rapid release, while the concentration in the urine is much higher than in the blood.

Metabolism

Slightly biotransformed (<10%).

breeding

Unlike nitrofurantoin (furadonin), urine pH does not change after taking Furamag. 4 hours after taking the drug, the concentration of furazidin in the urine significantly exceeds the concentration that is formed after taking the same dose of furagin.

Excreted by the kidneys by glomerular filtration and tubular secretion (85%), partially undergoes reverse reabsorption in the tubules. At low concentrations of furazidin in the urine, the process of filtration and secretion predominates, at high concentrations secretion decreases and reabsorption increases. Furazidin, being a weak acid in acidic urine, does not dissociate, undergoes intensive reabsorption, which can increase the development of systemic side effects. With an alkaline urine reaction, the excretion of furazidin is enhanced.

Pharmacokinetics in special clinical situations

With a decrease in the excretory function of the kidneys, the intensity of metabolism increases.

Indications

Infections caused by susceptible microorganisms:

- urogenital infections (acute cystitis, urethritis, pyelonephritis);

- gynecological infections;

- infections of the skin and soft tissues;

- severe infected burns;

- for prophylactic purposes during urological operations (including cystoscopy, catheterization).

Dosing regimen

The drug should be taken orally after meals.

Adults are prescribed 50-100 mg 3 times / day.

Children over 3 years of age are prescribed 25-50 mg (no more than 5 mg / kg of body weight) 3 times / day.

The course of treatment is 7-10 days. If you need to repeat the course of treatment, you should take a break for 10-15 days.

For the prevention of infection (including during urological operations, cystoscopy, catheterization), the drug is prescribed 50 mg once 30 minutes before the procedure.

If a dose is missed, the next dose should be taken at the usual time. Do not take a double dose to make up for a missed dose.

Side effect

From the digestive system: rarely - nausea, vomiting, loss of appetite, abnormal liver function.

From the side of the central nervous system and peripheral nervous system: rarely - headache, dizziness, polyneuritis.

Allergic reactions: rarely - skin rash (including papular rashes).

Furamag is low toxic.

Contraindications

- severe chronic renal failure;

- pregnancy;

- lactation period (breastfeeding);

- children's age up to 3 years;

- Hypersensitivity to drugs of the nitrofuran group.

With caution, use the drug deficiency of glucose-6-phosphate dehydrogenase, during the neonatal period.

Use during pregnancy and lactation

The use of the drug during pregnancy and lactation (breastfeeding) is contraindicated.

Application for violations of kidney function

Toxic effects as a result of the use of the drug are more likely to occur in patients with reduced renal excretory function (intensity of furazidin metabolism increases).

special instructions

To reduce the likelihood of side effects, Furamag is washed down with a large amount of liquid.

If side effects occur, the use of the drug should be discontinued (toxic effects are more common in patients with reduced renal excretory function).

The patient should inform the doctor about any side effects that occur during treatment with the drug.

Influence on the ability to drive vehicles and control mechanisms

No effect on the ability to drive vehicles and control mechanisms was noted.

Overdose

Symptoms: neurotoxic manifestations, ataxia, tremor.

Treatment: drink plenty of fluids. Antihistamines (diphenhydramine) are used to relieve acute symptoms. For the prevention of neuritis, it is possible to prescribe vitamins (thiamine bromide).

drug interaction

Furamag should not be used simultaneously with ristomycin, chloramphenicol, sulfonamides (the risk of hematopoiesis inhibition increases).

Terms of dispensing from pharmacies

The drug is dispensed by prescription.

Terms and conditions of storage

The drug should be stored out of the reach of children, dry, dark place at a temperature not exceeding 25°C. Shelf life - 3 years.

Olainfarm JSC

Country of origin

Latvia

Product group

Antibacterial drugs

Antimicrobial agent - nitrofuran

Release form

  • 10 - blisters (3) - packs of cardboard.

Description of the dosage form

  • Capsules hard gelatin, size No. 4, brownish-yellow; the contents of the capsules are orange-brown to reddish-brown powder, white, yellow, orange and orange-brown particles are allowed.

pharmachologic effect

A broad-spectrum antimicrobial agent belonging to the group of nitrofurans. Resistance to Furamag develops slowly and does not reach a high degree. Active against gram-positive cocci: Streptococcus spp., Staphylococcus spp.; gram-negative rods: Escherichia coli, Salmonella spp., Shigella spp., Proteus mirabilis, Klebsiella spp., Enterobacter spp.; protozoa: Lamblia intestinalis and other microorganisms resistant to antibiotics. In relation to Staphylococcus spp., Escherichia coli, Aerobacter aerogenes, Leuconostoc citrovorum, Proteus mirabilis, Proteus morganii, Furamag® is more active than other nitrofurans. Against most bacteria, the bacteriostatic concentration ranges from 1:100,000 to 1:200,000. The bactericidal concentration is about 2 times higher. Under the influence of nitrofurans in microorganisms, the respiratory chain and the tricarboxylic acid cycle (Krebs cycle) are suppressed, as well as other biochemical processes of microorganisms are suppressed, resulting in the destruction of their shell or cytoplasmic membrane. As a result of the action of nitrofurans, microorganisms release less toxins, and therefore an improvement in the general condition of the patient is possible even before a pronounced suppression of the growth of microflora. Nitrofurans activate the body's immune system: they increase the complement titer and the ability of leukocytes to phagocytize microorganisms. Furazidin in therapeutic doses stimulates leukopoiesis.

Pharmacokinetics

Absorption After oral administration, furazidin is absorbed in the small intestine by passive diffusion. The absorption of nitrofurans from the distal segment of the small intestine exceeds the absorption from the proximal and medial segments by 2 and 4 times, respectively (should be taken into account in the simultaneous treatment of urogenital infections and gastrointestinal diseases, in particular chronic enteritis). Nitrofurans are poorly absorbed from the colon. Cmax in blood plasma lasts from 3 to 7 or 8 hours, furazidin is detected in urine after 3-4 hours. furazidin (after taking the capsule of Furamag in the acidic environment of the stomach, there is no conversion of potassium furazidin into poorly soluble furazidin). Distribution In the body, furazidin is distributed evenly. Clinically important is the high content of the drug in the lymph (delays the spread of infection through the lymphatic tract). In bile, its concentration is several times higher than in serum, and in cerebrospinal fluid - several times lower than in serum. In saliva, the furazidin content is 30% of its serum concentration. The concentration of furazidin in the blood and tissues is relatively low, which is associated with its rapid release, while the concentration in the urine is much higher than in the blood. Metabolism Slightly biotransformed (

Special conditions

To reduce the likelihood of side effects, Furamag® is washed down with a large amount of liquid. If side effects occur, the use of the drug should be discontinued (toxic effects are more common in patients with reduced renal excretory function). The patient should inform the doctor about any side effects that occur during treatment with the drug. During the period of treatment, the patient is advised to refrain from drinking alcoholic beverages, since side effects may increase. Influence on the ability to drive vehicles and control mechanisms No effect on the ability to drive vehicles and control mechanisms was noted.

Compound

  • 1 caps. furazidin potassium - 25 mg Excipients: magnesium hydroxycarbonate - 25 mg, potassium carbonate - 6.3 mg, talc - 1.5 mg Composition of gelatin capsule No. 4: titanium dioxide (E171) - 3% iron dye yellow oxide (E172) - 0.73 % gelatin - 96.27%

Furamag indications for use

  • Infections caused by susceptible microorganisms: - urogenital infections (acute cystitis, urethritis, pyelonephritis); - gynecological infections; - skin and soft tissue infections; - severe infected burns; - for prophylactic purposes during urological operations (including cystoscopy, catheterization).

Furamag contraindications

  • - severe chronic renal failure; - pregnancy; - lactation period (breastfeeding); - children's age up to 3 years (for this dosage form); - hypersensitivity to drugs of the nitrofuran group. With caution, the drug is used with a deficiency of glucose-6-phosphate dehydrogenase, during the neonatal period.

Furamag dosage

  • 25 mg 50 mg

Furamag side effects

  • From the digestive system: rarely - nausea, vomiting, loss of appetite, abnormal liver function. From the side of the central nervous system and peripheral nervous system: rarely - headache, dizziness, polyneuritis. Allergic reactions: rarely - skin rash (including papular rashes). Furamag® has low toxicity.

drug interaction

Furamag® should not be used simultaneously with ristomycin, chloramphenicol, sulfonamides (the risk of hematopoietic inhibition increases). It is not recommended to prescribe drugs that can acidify urine (including ascorbic acid, calcium chloride) simultaneously with nitrofurans.

Overdose

Symptoms: neurotoxic manifestations, ataxia, tremor. Treatment: drink plenty of fluids. Antihistamines (diphenhydramine) are used to relieve acute symptoms. For the prevention of neuritis, it is possible to prescribe vitamins (thiamine bromide).

Storage conditions

  • store in a dry place
  • keep away from children
  • store in a place protected from light
Information provided by the State Register of Medicines.

Synonyms

  • Furagin, Furagin soluble, Furagin-standard

The drug "Furamag" is a highly effective uroantiseptic drug, which belongs to the nitrofuran group. It is known about a new medicinal soluble form of the drug "Furomag". From which it has a high antibacterial activity, low toxicity and a wide spectrum of action.

Therapeutic effect of the drug "Furamag"

What does the drug allow you to get rid of? The agent and its analogues are responsible for delaying the development and growth of gram-negative and gram-positive microbes that are resistant to other drugs with antimicrobial action. Capsules are active against Gram-negative rods, destroying Enterobacteriaceae, Proteus, Klebsiella, Eisherichia coli, Shigella, Salmonella, as well as Staphylococcus, Giardia, Streptococcus. As the reviews show, "Furamag" not only does not reduce immunity, but also activates, stimulating the processes of reproduction of leukocytes.

Medication "Furamag": from what to take

The drug is prescribed for the treatment of such ailments as:

  • soft tissue infections
  • cholecystitis,
  • skin infections,
  • sepsis,
  • bronchitis,
  • pneumonia,
  • gynecological infections,
  • infected burns,
  • respiratory pathology,
  • infectious inflammatory processes in the urinary system,
  • urethritis,
  • pyelonephritis,
  • cystitis.

Another medicine is taken to prevent infections during urological operations, catheterization, cystoscopy.

Analogues

Structural medicines with a similar therapeutic effect include the drugs Furagin, Furasol, Furazidin.

Release form and composition

The medicine is produced in the form of powder and gelatin capsules. Each dragee contains active ingredients - magnesium hydroxycarbonate and furazidin potassium salt. Additional components include talc, potassium carbonate.

How to take "Furamag"

The medicine is used intravenously, intrabronchially, intratracheally, orally. Sometimes local use of the drug is practiced. The daily dose for adults is 15-300 mg three times. Children weighing 30 kg or more are prescribed 50 mg of the drug three times a day. For children from one to ten years old, the daily dose according to the instructions is 5 mg / kg of body in several doses. The duration of therapy is seven to ten days.

Contraindications

It is forbidden to use the drug for diseases such as:

  • polyneuritis,
  • polyneuropathy,
  • kidney failure,
  • toxic hepatitis,
  • hypersensitivity.

You can not take the medicine during lactation, during pregnancy, as well as children under three years of age. Capsules are taken with caution in case of pathologies of the liver and nervous system, deficiency of glucose phosphate dehydrogenase, renal failure.

Side effect of the drug "Furamag"

Prolonged liver dysfunction, allergic reactions, dizziness, loss of appetite, nausea, headache. Do not take the drug together with calcium chloride, ascorbic acid, sulfonamides, ristomycin, chloramphenicol, alcoholic beverages.

Antibacterial drug, a derivative of nitrofuran

Active substance

Furazidin (furazidin)

Release form, composition and packaging

Capsules hard gelatin, size No. 4, brownish yellow; the contents of the capsules are orange-brown to reddish-brown powder, white, yellow, orange and orange-brown particles are allowed.

Excipients: potassium carbonate - 6.3 mg, magnesium hydroxycarbonate - 25 mg, talc - 1.5 mg.

Composition of gelatin capsule No. 4: gelatin - 96.27%, iron dye yellow oxide (E172) - 0.73%, titanium dioxide (E171) - 3%.




Capsules hard gelatin, size No. 3, yellow; the contents of the capsules are orange-brown to reddish-brown powder, white, yellow, orange and orange-brown particles are allowed.

Excipients: potassium carbonate - 12.6 mg, magnesium hydroxycarbonate - 50 mg, talc - 3 mg.

The composition of the gelatin capsule No. 3: gelatin - 97.48%, quinoline yellow dye (E104) - 1.2%, titanium dioxide (E171) - 1.32%.

10 pieces. - blisters (2) - packs of cardboard.
10 pieces. - blisters (3) - packs of cardboard.
10 pieces. - blisters (4) - packs of cardboard.
10 pieces. - blisters (5) - packs of cardboard.

pharmachologic effect

Excreted by the kidneys by glomerular filtration and tubular secretion (85%), partially undergoes reverse reabsorption in the tubules. At low concentrations of furazidin in the urine, the process of filtration and secretion predominates, at high concentrations secretion decreases and reabsorption increases. Furazidin, being a weak acid, does not dissociate in acidic urine, undergoes intensive reabsorption, which can increase the development of systemic side effects. With an alkaline urine reaction, the excretion of furazidin is enhanced.

Pharmacokinetics in special clinical situations

With a decrease in the excretory function of the kidneys, the intensity of metabolism increases.

Indications

Infections caused by microorganisms sensitive to furazidin:

- urogenital infections (acute cystitis, urethritis, pyelonephritis);

- gynecological infections;

- infections of the skin and soft tissues;

- severe infected burns;

- for prophylactic purposes during urological operations (including cystoscopy, catheterization).

Contraindications

- chronic severe;

- pregnancy;

- lactation period (breastfeeding);

- children's age up to 3 years (for this dosage form);

- Hypersensitivity to drugs of the nitrofuran group.

Carefully use the drug for deficiency of glucose-6-phosphate dehydrogenase, renal failure.

Dosage

The drug should be taken orally after meals with plenty of liquid.

Adults appoint 50-100 mg 3 times / day.

children appoint 25-50 mg 3 times / day (but not more than 5 mg / kg of body weight per day).

The course of treatment is 7-10 days. If you need to repeat the course of treatment, you should take a break for 10-15 days.

For prevention of infection during urological operations, cystoscopy, catheterization, etc. the drug is prescribed adults 50 mg each children- 25 mg once 30 minutes before the procedure.

If a dose is missed, the next dose should be taken at the usual time. Do not take a double dose to make up for a missed dose.

Side effects

From the digestive system: rarely - nausea, vomiting, loss of appetite, abnormal liver function.

From the side of the central nervous system and peripheral nervous system: rarely - headache, dizziness, polyneuritis.

Allergic reactions: rarely - skin rash (including papular rashes).

Furamag is low toxic.

Overdose

Symptoms: neurotoxic manifestations, ataxia, tremor.

Treatment: you should drink plenty of fluids. Antihistamines are used to relieve acute symptoms. For the prevention of neuritis, it is possible to prescribe (thiamine bromide).

drug interaction

Furamag should not be used simultaneously with ristomycin, chloramphenicol, sulfonamides (the risk of hematopoiesis inhibition increases).

special instructions

To reduce the likelihood of side effects, Furamag is washed down with a large amount of liquid.

If side effects occur, the use of the drug should be discontinued (toxic effects are more common in patients with reduced renal excretory function).

The patient should inform the doctor about any side effects that occur during treatment with the drug.

Influence on the ability to drive vehicles and mechanisms

No effect on the ability to drive vehicles and control mechanisms was noted.

Pregnancy and lactation

The use of the drug during pregnancy and lactation (breastfeeding) is contraindicated.

Application in childhood

Contraindicated in children under 3 years of age.

For impaired renal function

Contraindicated in severe chronic renal failure.

Toxic effects as a result of the use of the drug are more likely to occur in patients with reduced renal excretory function (intensity of furazidin metabolism increases).

Terms of dispensing from pharmacies

The drug is dispensed by prescription.

Terms and conditions of storage

The drug should be stored out of the reach of children, dry, dark place at a temperature not exceeding 25°C. Shelf life - 3 years.